Scientifically proven to increase cognitive skills and improve math and reading scores

Developed by world’s leading neuroscientists


Students in classes that used ACTIVATE™ had significantly greater gains on school-administered tests of math and reading proficiency compared to students in classes that did not use ACTIVATE™.*

*Study of over 500 2nd graders in an affluent suburban town.

Wexler, Bruce E., Markus Iseli, Seth Leon, William Zaggle, Cynthia Rush, Annette Goodman, A. Esat Imal, and Emily Bo. “Cognitive priming and cognitive training: immediate and far transfer to academic skills in children.” Scientific reports 6 (2016):

ACTIVATE™ increased the number of students that were proficient in math nearly 6 times!

ACTIVATE™ increased the number of students that were proficient in reading nearly 4 times!

ACTIVATE™ closes the achievement gap!

4x as many children using ACTIVATE™ were able to gain two years of reading competency in one school year vs students who did not use ACTIVATE™.

Three lowest performing schools in a large school district

ACTIVATE™ Improves  The Ability To Learn

 Cognitive improvement in 1000 K-8 Students on ACTIVATE™.

Kavanaugh, B. C., Tuncer, O. F., & Wexler, B. E. (2018). Measuring and Improving Executive Functioning in the Classroom. Journal of Cognitive Enhancement, 1-10

ACTIVATE™ Increases School-Readiness

Students who used ACTIVATE™ in kindergarten started first grade ahead of classmates who did not.

Imal, A. and Wexler, B. (2018) Increasing Readiness to Learn: Benefits of Executive Function Training in Kindergarten Carry over to First Grade. Creative Education, 9, 2662-2676. doi: 10.4236/ce.2018.916201.

The Neuroscience Behind ACTIVATE™ Brain Training

Meet Bruce E. Wexler, MD

Founder and Chief Scientific Officer of C8 Sciences, is professor of psychiatry at Yale School of Medicine. In 45 years of neuroscience research, he has advanced the understanding of brain plasticity and been an international leader in developing computer-presented brain exercises to improve executive cognitive functions. His patent-pending innovations led to the development of the ACTIVATE™ cognition cross-training program for children that integrates computer-presented and physical exercises to improve executive function skills essential for learning. For this work, he received an NIH Director’s Award for “high innovation, high impact, paradigm-changing” research. Dr. Wexler’s book Brain and Culture: Neurobiology, Ideology, and Social Change (MIT Press; Chinese translation Zhejiang University Press) has received international attention. Oliver Sacks called it “a major achievement, touching the deepest biological and human issues…a very powerful and very important book.” Professor Howard Gardner of Harvard University School of Education called it “A pioneering and bold effort to construct a bridge between scientific findings about the brain and the diversity, strengths, and fragilities of human cultures.” Dr. Wexler has given multiple academic and public lectures in North and South America, Europe and Asia. He is a consultant for the Kennedy Foundation Forum on Technology and Mental Health Innovations and BrainFutures, and previously served as a consultant for the GE Brain Trust and the Gates Foundation.

Dr. Wexler graduated magna cum laude from Harvard University, studied psychiatry at Anna Freud’s Hampstead Clinic and Neurology at the Institute of Neurology, Queen’s Square, London. He received his Doctor of Medicine from Albert Einstein College of Medicine and training in psychiatry at Yale.

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Learn more about the cognitive neuroscience behind ACTIVATE™ in the scientific justification paper by Dr. Bruce Wexler.