Clinically Proven to Reduce the Effects of Depression, Anxiety and ADHD, and Improve Learning Outcomes

Developed by World-leading Neuroscientists at Yale University

Below you will find 30 peer-reviewed research papers published in leading scientific journals that were authored by C8’s founder, Dr. Bruce Wexler and his colleagues at Yale University School of Medicine and around the world. These papers describe the technology that underlies our products and the successful clinical trials that have been run using the cognitive exercises in our products such as the “catch the ball” exercises that were the primary component of the intervention in the depression trials.

Blue text is for Adult Brain Health articles
Red Text is for Child Brain Health and Learning articles


Morimoto S, Altizer R, Gunning F, Liu J, Cote S, Nitis J, Alexopoulos G. May 2020 Targeting Cognitive Control Deficits With Neuroplasticity-Based Computerized Cognitive Remediation in Patients With Geriatric Major Depression: A Randomized, Doble-Blind, Controlled Trial. The American Journal of Geriatric Psychiatry

Wexler BE, Vitulano LA, Moore C, Katsovich L, Smith SD, Rush C, Grantz, H, Dong J, Leckman JF. (2020: 1-12): An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder. Psychological Medicine

Wexler BE, Imal AE, Pittman B, Bell MB. (2020 11: 1-14): Executive function deficits mediate poverty’s effects on academic achievement: Target for intervention in at-risk children. Creative Education

Imal AE, O’Leary S, Wexler BE. (2020 (in press)): Identification of maladaptive risk-taking patterns and associated cognitive weaknesses in children: An opportunity for primary-prevention of negative health outcomes from high-risk behaviors in adolescence? Psychiatric Research and Clinical Practice .


Kavanaugh B, Tuncer O, Wexler BE. (2019 3: 271-280): Measuring and Improving Executive Function in the Classroom. J of Cognitive Enhancement

Surti TS, Vinogradov, S, Bell MD, Wexler BE. (2019 doi: 10.1016/j.schres.2019.11.021): Improvement on visual cognitive training exercises in schizophrenia is present but less robust than in healthy individuals. Schizophrenia Research

Bell MD, Imal AE, Pittman B, Wexler BE. (2019 17: 100120): The development of adaptive risk taking and the role of executive functions in a large sample of school-age boys and girls. Trends in Neuroscience and Education Science Direct

Smith SS, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG. (2019: 278: 248-257): Effects of a brain, body and social (IBBS), intervention on ERP measures of attentional control on children with ADHD. Psychiatry Research


Imal AE, Wexler BE. (2018 10.4236/ce.2018.916201): Increasing readiness to learn: benefits of executive function training in kindergarten carry over to first grade. Creative Education

Sinnari, Doaa & Krause, Paul & Abulkhair, Maysoon. (2018). Effects of E-Games on the Development of Saudi Children with Attention Deficit Hyperactivity Disorder Cognitively, Behaviourally and Socially: An Experimental Study. 10.1007/978-3-319-92049-8_44.


Corbera, S., Wexler, B.E., Poltorak, A., Thime, W.R., Kurtz, M.M. (2017:247:21-27): Cognitive remediation for adults with schizophrenia: Does age matter? Psychiatry Research.


Wexler, B. E. et al. (2016, 6, 32859; doi: 10.1038/srep32859): Cognitive Priming and Cognitive Training: Immediate and FarTransfer to Academic Skills in Children. Nature Scientific Reports


Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. (August 5, 2014): Neuroplasticity-based computerized cognitive remediation for treatment resistant geriatric depression. Nature Communications

Morris D. Bell, Kee-Hong Choi, Christina Dyer, Bruce E. Wexler. (April, 2014): Benefits of Cognitive Remediation and Supported Employment for Schizophrenia Patients With Poor Community Functioning. Psychiatric Services


Wexler BE.(2013: 5:1-17): Integrated Brain and Body Exercises for ADHD and Related Problems with Attention and Executive Function. International Journal of Gaming and Computer-Mediated Simulations


Surti TS, Wexler BE. (2012:142: 248-249): A pilot and feasibility study of computer-based training for visual processing deficits in schizophrenia. Schizophrenia Research


Kurtz MM. Seltzer JC. Fujimoto M. Shagan DS. Wexler BE. (2009: 107:267-74.): Predictors of change in life skills in schizophrenia after cognitive remediation. Schizophrenia Research


Bell MD, Zito W, Greig T, Wexler BE (2008: 105:18-29): Neurocognitive Enhancement Therapy with Vocational Services in Schizophrenia: Work Outcomes at Two Year Follow-Up. Schizophrenia Research


Kurtz, M.M., Seltzer, J.C., Shagan, D.S., Thime, W.R., Wexler, B.E. (2007:89:251-260): Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient? Schizophrenia Research

Bell, M, Fiszdon, J, Greig, T, Wexler, BE, Bryson, G. (2007:44:761-770): Neurocognitive enhancement therapy with work therapy in schizophrenia: A 6-month follow-up of neuropsychological performance. Journal of Rehabilitation Research and Development

Greig TC. Zito W. Wexler BE. Fiszdon J. Bell MD. (2007: 96(1-3):156-61): Improved cognitive function in schizophrenia after one year of cognitive training and vocational services. Schizophrenia Research .


Fiszdon, J, Whelahan, H., Bryson. G., Silverstein, S., Wexler, B., Bell, M. (2005, 112:187-193): Cognitive Training of Verbal Memory Using a Dichotic Listening Paradigm: Impact on Symptoms and Cognition in Schizophrenia. Acta Psychiatrica Scandinavia

Kurtz, M.M., Seltzer, J.C., Shagan, D.S., Wexler, B.E. (2005, 31(2): 330-330): Neurocognitive remediation for patients with schizophrenia: How specific is the intervention and its effects? Schizophrenia Bulletin

Bell MD, Bryson GJ, Greig TC, Fiszdon JM, Wexler BE. (2005, 31(2): 518-519): Functional outcomes from a RCT of cognitive training and work therapy: 12 month follow-up. Schizophrenia Bulletin

Bryson GJ, Bell MD, Greig TC, Wexler BE. (2005, 31(2): 520-521): Neuropsychological outcomes from a RCT of cognitive training and work therapy: 12 month follow-up. Schizophrenia Bulletin

Bell MD, Bryson GJ, Greig TC, Fiszdon JM, Wexler BE. (2005, 42:829-838): Neurocognitive Enhancement Therapy with Work Therapy: Productivity Outcomes at 6 and 12 month follow-up. Journal of Rehabilitation Research and Development

Wexler, BE, Bell MD. (2005, 31(4):931-941): Cognitive Remediation and Vocational Rehabilitation for Schizophrenia. Schizophrenia Bulletin


Fiszdon JM, Bryson GJ, Wexler BE, Bell MD. (2004, 125:1-7): Durability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up. Psychiatry Research

Bell MD, Fiszdon J, Bryson G, Wexler BE. (2004, 9:199-211): Effects of neurocognitive enhancement therapy in schizophrenia: Normalisation of memory performance. Cognitive Neuropsychiatry


Bell MD, Bryson G, Wexler BE (2003, 108:101-9): Cognitive remediation of working memory deficits: durability of training effects in severely and less severely impaired schizophrenia. Acta Psychiatrica Scandanavia


Bell M, Bryson G, Tasamine Greig, PhD, Cheryl Corcoran, MD, Wexler BE (2001, 58:763-768): Neurocognitive enhancement therapy with work therapy: Effects on neuropsychological test performance. Archives of General Psychiatry


Wexler BE, Anderson M, Fulbright RK, Gore JC.(2000, 157:1094-1097): Improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises. American Journal of Psychiatry


Wexler BE, Hawkins KA, Rounsaville B, Anderson M, Sernyak MJ, Green MF (1997, 26: 173-180): Normal neurocognitive performance after extended practice in patients with schizophrenia. Schizophrenia Research

The Neuroscience Behind ACTIVATE™ Brain Training

Meet Bruce E. Wexler, MD

Bruce WexlerFounder and Chief Scientific Officer of C8 Sciences, is professor of psychiatry at Yale School of Medicine. In 45 years of neuroscience research, he has advanced the understanding of brain plasticity and been an international leader in developing computer-presented brain exercises to improve executive cognitive functions. His patent-pending innovations led to the development of the ACTIVATE™ cognition cross-training program for children that integrates computer-presented and physical exercises to improve executive function skills essential for learning. For this work, he received an NIH Director’s Award for “high innovation, high impact, paradigm-changing” research. Dr. Wexler’s book Brain and Culture: Neurobiology, Ideology, and Social Change (MIT Press; Chinese translation Zhejiang University Press) has received international attention. Oliver Sacks called it “a major achievement, touching the deepest biological and human issues…a very powerful and very important book.” Professor Howard Gardner of Harvard University School of Education called it “A pioneering and bold effort to construct a bridge between scientific findings about the brain and the diversity, strengths, and fragilities of human cultures.” Dr. Wexler has given multiple academic and public lectures in North and South America, Europe and Asia. He is a consultant for the Kennedy Foundation Forum on Technology and Mental Health Innovations and BrainFutures, and previously served as a consultant for the GE Brain Trust and the Gates Foundation.

Dr. Wexler graduated magna cum laude from Harvard University, studied psychiatry at Anna Freud’s Hampstead Clinic and Neurology at the Institute of Neurology, Queen’s Square, London. He received his Doctor of Medicine from Albert Einstein College of Medicine and training in psychiatry at Yale.

Sign-Up for ACTIVATE™ Today!

Ask a Question

Do you have a question that can be answered by Dr. Bruce Wexler? Submit it below!